Nano-diamond cancer gene therapy new dawn

Abstract Nanomaterials have become a hot topic in the scientific community because of their unique five major effects: volume effect, surface effect, quantum size effect, macroscopic quantum tunneling effect and dielectric confinement effect. Mr. Qian Yitai, Dean of School of Chemistry and Materials, University of Science and Technology of China...

Nanomaterials have become a hot topic in the scientific community because of their unique five major effects: volumetric effects, surface effects, quantum size effects, macroscopic quantum tunneling, and dielectric confinement effects.

Mr. Qian Yitai, Dean of School of Chemistry and Materials, University of Science and Technology of China

Academician of the Chinese Academy of Sciences, Dean of the School of Chemistry and Materials, University of Science and Technology of China, Mr. Qian Yitai and others used catalytic pyrolysis to react carbon tetrachloride and sodium to prepare diamond nanopowder. To this end, the US Chemical and Engineering News magazine highly praised the work of synthesizing diamonds using the above techniques, using the title "Straws to Gold - From CCI4 to Diamonds". In recent years, the process of synthesizing nanodiamonds by the impact method (dynamic pressure method) has also been improved.

Experiments have shown that n m D (nano-diamond) can be added to almost all materials to improve its performance. Today's nano-diamonds are not limited to the field of abrasives such as polycrystals and polishing agents. With the deepening of the understanding of nano-diamond properties, nano-diamonds have begun in the fields of metal plating, lubricating oil, magnetic recording systems, and medicine. Get the app and the application area is expanding.

This article will focus on combing some of the applications of nanodiamonds in medicine.

Cancer has always been a key topic and problem that has plagued countless researchers in medicine. Through continuous exploration, we now know the promising prospects of gene therapy in treating this disease. However, traditional gene therapy is difficult to integrate efficient delivery and biocompatibility into a gene delivery system. However, researchers at Northwestern University found that nanodiamonds, as a novel gene delivery technology, can combine transmission efficiency and biocompatibility in a drug delivery packaging system.

Using the innate advantages of nanodiamonds, researchers have seen the prospect of nanodiamonds in gene therapy. The researchers describe that the designed surface-modified nanodiamond particles can successfully and efficiently transport DNA into mammalian cells, and the transmission efficiency is 70 times higher than the current standard of gene therapy. They functionalized the nanodiamond surface with the low molecular weight polymer PEI800 to achieve a uniformity of efficiency and safety. The PEI800 and nanodiamond junctions are 70 times more efficient than the PEI800 alone, and the biocompatibility of the PEI800 is retained. The high degree of extensibility of this process increases the ability of gene transfer.

On June 6, Jiang Mianheng, Dean of the Shanghai Branch of the Chinese Academy of Sciences, and John A. Fry, President of Drexel University, unveiled the joint center. At present, the center has used nano-diamond as the main research object, and it has been applied to drug delivery and in vivo diagnosis with its excellent mechanical properties, diverse surface chemical properties, good chemical stability and high biocompatibility. Research work in the fields of tissue engineering and thermotherapy. We believe that through the study of the functionalization of nanodiamonds, humans will eventually find a powerful weapon in the fight against cancer.

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